Abstract P26

Abstract P26: Prophylactic Regenerative Peripheral Nerve Interfaces for the Mitigation of Neuroma Pain and Phantom Limb Pain

PURPOSE: Regenerative Peripheral Nerve Interfaces (RPNIs) can be used to treat symptomatic end neuromas that develop after major limb amputation. Symptomatic neuromas occur in approximately 30–40% of individuals after limb loss and phantom limb pain affects 70–95% of these patients. We investigate the potential of prophylactic RPNIs to prevent neuroma formation and to mitigate the experience of...

Abstract P26. The Ratio And Time Effect: Administration Of Il-2-anti-il-2 Complexes Controls Vascularized Composite Allograft Survival.

METHODS: We performed the VCA model utilizing Balb/c mice as donor and C57bl/10 mice as recipient. Mice were divided randomly to 6 groups (n=15/group). Group A: control; Group B: post-Tx. IL-2C (inj. POD 0, 1, 2); Group C: Rapamycin (2mg/kg, 28days); Group D: Rapamycin plus post-Tx. IL-2C; Group E: pre-Tx. IL-2C (POD -5, -4, -3); Group F: Rapamycin plus pre-Tx. IL-2C. Signs of allograft rejecti...

abstract

ABSTRACT

Abstract

Abstract